PETRULIS - DE VRIES LAB
PETRULIS - DE VRIES LAB
Sex differences in Neural Control of Social Behavior and Communication
Welcome to the Laboratory of Aras Petrulis and Geert J. de Vries at Georgia State University located in downtown Atlanta, Georgia. Petrulis and de Vries run a collaborative laboratory that explores the neural regulation of social and communicative behavior, with an emphasis on sex differences in these processes.
Current projects in the lab focus on the role of the neuropeptide vasopressin and its receptor systems in the regulation of social, communicative and emotional behavior.
PROJECTS
Investigating the social and emotional role of the vasopressin system
VASOPRESSIN PEPTIDE
Disorders of social behavior and communication are increasingly common and pose a substantial burden to society. These disorders, such as autism, often show sex differences in prevalence, expression, and severity. One explanation for these differences reflects dysfunction in the sexually different social brain. A particularly relevant neuropeptide system in this respect is the vasopressin (VP) innervation of the brain, which shows marked sex differences across many species, including humans, and has been implicated in aggressive as well as affiliation behavior. We are using modern viral and genetic techniques to specifically and directly target the sex-different VP cells in the extended amygdala as well as other VP cells in hypothalamus in order to understand their behavioral function as well as their inputs and outputs. Published work was funded by the National Institute of Mental Health (R01 MH121603) and is currently funded by NIMH as well (R01 MH135553).
VASOPRESSIN RECEPTORS
The main receptor for vasopressin in the brain, vasopressin 1a receptor (Avpr1a or V1aR), has been repeatedly implicated in social and emotional behavior and has been a major target for drug development for treating core symptoms of autism. Consequently, we are assessing, using pharmacological, viral and genetic techniques, how, when, and where V1aR signaling in brain influences social approach and communication behavior in adult mice. This work was (R03 MH120549) and is (R01 MH135553) funded by the National Institute of Mental Health as well as the GSU Brains and Behavior Program.
CONTACT US
Neuroscience Institute, Georgia State University
100 Piedmont Avenue SE
Atlanta, Georgia, USA 30303
